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North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
The aim of the present work was to study the effect of the drug CoQ10 «Kudesan» in different concentrations on the respiratory chain and the related effects. The experiment was performed with the use of donor leukocytes, which were incubated with a solution of CoQ10 in various concentrations. It is established that the best influence on the energy metabolism of cells has CoQ10 (drug «Kudesan») at concentrations close to 0,0121 and 0,024 mmol /ml, with not only increased the activity of complexes I and IV, but also the efficiency of the respiratory chain. Also on the results obtained allow us to judge the increasing share of aerobic oxidation-reduction processes in the energy metabolism of the cells under the influence of the drug CoQ10 «Kudesan».
Key words: respiratory chain, CoQ10, Kudesan, leukocytes.
Contact: L.G. Mishura, e-mail: doctormlg@mail.ru
